Cell Senescence Entries for CHEK1

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
CHEK1 knockdown resulted in a reduced G2 checkpoint arrest upon H2O2-induced senescence, both in wild type and p53 deficient cells. CHEK1 was shown to be required for G1 checkpoint arrest and knocking it down reversed the senescent phenotype.
Primary Reference

    CHEK1 Gene Information

    HGNC symbol
    CHEK1 
    Aliases
    CHK1 
    Common name
    checkpoint kinase 1 
    Entrez Id
    1111
    Description
    The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

    CHEK1 Ontologies

    Gene Ontology
    Process: GO:77; DNA damage checkpoint
    GO:6975; DNA damage induced protein phosphorylation
    GO:6281; DNA repair
    GO:6260; DNA replication
    GO:31572; G2 DNA damage checkpoint
    GO:7049; cell cycle
    GO:6974; cellular response to DNA damage stimulus
    GO:71260; cellular response to mechanical stimulus
    GO:48096; chromatin-mediated maintenance of transcription
    GO:35407; histone H3-T11 phosphorylation
    GO:35556; intracellular signal transduction
    And 10 more GO terms
    Cellular component: GO:5813; centrosome
    GO:785; chromatin
    GO:781; chromosome, telomeric region
    GO:794; condensed nuclear chromosome
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5615; extracellular space
    GO:43231; intracellular membrane-bounded organelle
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    And 1 more GO terms
    Function: GO:5524; ATP binding
    GO:35402; histone kinase activity (H3-T11 specific)
    GO:16301; kinase activity
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of CHEK1 in Model Organisms

    Caenorhabditis elegans
    chk-1
    Danio rerio
    chek1
    Drosophila melanogaster
    SNF1A
    Mus musculus
    Chek1
    Rattus norvegicus
    Chek1
    Saccharomyces cerevisiae
    CHK1
    Schizosaccharomyces pombe
    chk1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as chk-1
    • A homolog of this gene for Drosophila melanogaster is present as SNF1A

    External links

    OMIM
    603078
    Ensembl
    ENSG00000149554
    Entrez Gene
    1111
    UniGene
    24529
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CHEK1
    GeneCards
    CHEK1