Cell Senescence Entries for CENPA

Cell Types
Lung fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of CENP-A (CENPA) lead to premature senescence in human primary fibroblasts, dependent on p53 but not on p16. Additionally, CENP-A protein levels were diminished in senescent cells compared to young cells.
Primary Reference

    CENPA Gene Information

    HGNC symbol
    CENPA 
    Aliases
    CenH3; CENP-A 
    Common name
    centromere protein A 
    Entrez Id
    1058
    Description
    Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

    CENPA Ontologies

    Gene Ontology
    Process: GO:34080; CENP-A containing nucleosome assembly
    GO:132; establishment of mitotic spindle orientation
    GO:51382; kinetochore assembly
    GO:281; mitotic cytokinesis
    GO:71459; protein localization to chromosome, centromeric region
    GO:7062; sister chromatid cohesion
    GO:16032; viral process
    Cellular component: GO:775; chromosome, centromeric region
    GO:939; condensed chromosome inner kinetochore
    GO:778; condensed nuclear chromosome kinetochore
    GO:780; condensed nuclear chromosome, centromeric region
    GO:5829; cytosol
    GO:788; nuclear nucleosome
    GO:31618; nuclear pericentric heterochromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:3682; chromatin binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    Show all GO terms

    Homologs of CENPA in Model Organisms

    Mus musculus
    Cenpa
    Rattus norvegicus
    Cenpa

    External links

    OMIM
    117139
    Ensembl
    ENSG00000115163
    Entrez Gene
    1058
    UniGene
    1594
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CENPA
    GeneCards
    CENPA