Cell Senescence Entries for CEBPB

Cell Types
Prostate cancer
Cell Lines
LNCaP
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
Loss of C/EBP-beta (CEBPB) expression prevented growth arrest following androgen deprivation or anti-androgen challenge. Suppression of C/EBP-beta under low androgen conditions resulted in reduced expression of SASP genes, a decrease in SA-heterochromatin foci and increased numbers of Ki67-positive cells. Prostate cancer cells expressing C/EBP-beta exhibited morphological changes, reduced cell growth and increased senescence. It was also found that senescence contributed to cell survival under androgen deprivation, and C/EBP-beta-deficient cells were significantly more susceptible to killing by cytotoxic chemotherapy following androgen deprivation.
Primary Reference

    CEBPB Gene Information

    HGNC symbol
    CEBPB 
    Aliases
    TCF5; IL6DBP; NF-IL6; C/EBP-beta 
    Common name
    CCAAT/enhancer binding protein beta 
    Entrez Id
    1051
    Description
    This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

    CEBPB Ontologies

    Gene Ontology
    Process: GO:6953; acute-phase response
    GO:50873; brown fat cell differentiation
    GO:71230; cellular response to amino acid stimulus
    GO:71347; cellular response to interleukin-1
    GO:71222; cellular response to lipopolysaccharide
    GO:71407; cellular response to organic cyclic compound
    GO:42742; defense response to bacterium
    GO:1892; embryonic placenta development
    GO:72574; hepatocyte proliferation
    GO:6955; immune response
    GO:6954; inflammatory response
    And 22 more GO terms
    Cellular component: GO:36488; CHOP-C/EBP complex
    GO:779; condensed chromosome, centromeric region
    GO:5737; cytoplasm
    GO:790; nuclear chromatin
    GO:16363; nuclear matrix
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:35259; glucocorticoid receptor binding
    GO:35035; histone acetyltransferase binding
    GO:42826; histone deacetylase binding
    GO:19900; kinase binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    And 7 more GO terms
    Show all GO terms

    Homologs of CEBPB in Model Organisms

    Danio rerio
    cebpb
    Mus musculus
    Cebpb
    Rattus norvegicus
    Cebpb

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Cebpb
    GenAge human genes
    • This gene is present as CEBPB

    External links

    OMIM
    189965
    Ensembl
    ENSG00000172216
    Entrez Gene
    1051
    UniGene
    517106
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CEBPB
    GeneCards
    CEBPB