Cell Senescence Entries for CDKN2B
- Cell Types
- Glioblastoma
- Cell Lines
- T98G, U-251MG, U-373MG
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Promotes
- Observations
- Overexpression of p15 (CDKN2B) inhibited cell proliferation and caused replicative senescence in human glioma cells.
- Primary Reference
CDKN2B Gene Information
- HGNC symbol
- CDKN2B
- Aliases
- P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
- Common name
- cyclin dependent kinase inhibitor 2B
- Entrez Id
- 1030
- Description
- This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
CDKN2B Ontologies
- Gene Ontology
-
Process: GO:86; G2/M transition of mitotic cell cycle
GO:7050; cell cycle arrest
GO:31668; cellular response to extracellular stimulus
GO:31670; cellular response to nutrient
GO:30219; megakaryocyte differentiation
GO:7093; mitotic cell cycle checkpoint
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:8285; negative regulation of cell proliferation
GO:50680; negative regulation of epithelial cell proliferation
GO:42326; negative regulation of phosphorylation
GO:71901; negative regulation of protein serine/threonine kinase activity
And 5 more GO terms Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5634; nucleus
Function: GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:5515; protein binding
GO:19901; protein kinase binding
Homologs of CDKN2B in Model Organisms
- Danio rerio
- LOC100329528
- Mus musculus
- Cdkn2b
- Rattus norvegicus
- Cdkn2b
In other databases
External links
- OMIM
- 600431
- Ensembl
- ENSG00000147883
- Entrez Gene
- 1030
- UniGene
- 72901
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDKN2B
- GeneCards
- CDKN2B