Cell Senescence Entries for CDKN2B

Cell Types
Glioblastoma
Cell Lines
U-251MG, U-373MG, T98G
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of p15 (CDKN2B) inhibited cell proliferation and caused replicative senescence in human glioma cells.
Primary Reference

    CDKN2B Gene Information

    HGNC symbol
    CDKN2B 
    Aliases
    P15; MTS2; TP15; CDK4I; INK4B; p15INK4b 
    Common name
    cyclin dependent kinase inhibitor 2B 
    Entrez Id
    1030
    Description
    This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

    CDKN2B Ontologies

    Gene Ontology
    Process: GO:86; G2/M transition of mitotic cell cycle
    GO:7050; cell cycle arrest
    GO:31668; cellular response to extracellular stimulus
    GO:31670; cellular response to nutrient
    GO:30219; megakaryocyte differentiation
    GO:7093; mitotic cell cycle checkpoint
    GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
    GO:8285; negative regulation of cell proliferation
    GO:50680; negative regulation of epithelial cell proliferation
    GO:42326; negative regulation of phosphorylation
    GO:71901; negative regulation of protein serine/threonine kinase activity
    And 5 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5634; nucleus
    Function: GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
    GO:5515; protein binding
    GO:19901; protein kinase binding
    Show all GO terms

    Homologs of CDKN2B in Model Organisms

    Danio rerio
    LOC100329528
    Mus musculus
    Cdkn2b
    Rattus norvegicus
    Cdkn2b

    In other databases

    GenAge human genes
    • This gene is present as CDKN2B
    LongevityMap
    • This gene is present as CDKN2B

    External links

    OMIM
    600431
    Ensembl
    ENSG00000147883
    Entrez Gene
    1030
    UniGene
    72901
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN2B
    GeneCards
    CDKN2B