Cell Senescence Entries for CDKN2AIP

Cell Types
Lung fibroblast
Cell Lines
TIG-1, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
CARF (CDKN2AIP) was required for replicative and stress-induced senescence and its overexpression caused premature senescence in human fibroblasts. A lack of CARF caused aneuploidy and apoptosis.
Primary Reference

    CDKN2AIP Gene Information

    HGNC symbol
    CDKN2AIP 
    Aliases
    CARF 
    Common name
    CDKN2A interacting protein 
    Entrez Id
    55602
    Description
    The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

    CDKN2AIP Ontologies

    Gene Ontology
    Process: GO:6974; cellular response to DNA damage stimulus
    GO:30308; negative regulation of cell growth
    GO:30307; positive regulation of cell growth
    GO:9967; positive regulation of signal transduction
    GO:31647; regulation of protein stability
    Cellular component: GO:1652; granular component
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    Function: GO:3723; RNA binding
    GO:2039; p53 binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of CDKN2AIP in Model Organisms

    Mus musculus
    Cdkn2aip
    Rattus norvegicus
    Cdkn2aip

    External links

    OMIM
    615914
    Ensembl
    ENSG00000168564
    Entrez Gene
    55602
    UniGene
    592508
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN2AIP
    GeneCards
    CDKN2AIP