Cell Senescence Entries for CDKN2A

Cell Types
Lung fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
p16 (CDKN2A) is a common marker of senescence. Overexpression of p16 caused G1 arrest in early passage of human diploid fibroblasts, these also displayed several phenotypic features of cellular senescence.
Primary Reference

    CDKN2A Gene Information

    HGNC symbol
    CDKN2A 
    Aliases
    ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A 
    Common name
    cyclin dependent kinase inhibitor 2A 
    Entrez Id
    1029
    Description
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

    CDKN2A Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:7265; Ras protein signal transduction
    GO:7050; cell cycle arrest
    GO:90398; cellular senescence
    GO:32088; negative regulation of NF-kappaB transcription factor activity
    GO:30308; negative regulation of cell growth
    GO:8285; negative regulation of cell proliferation
    GO:1953; negative regulation of cell-matrix adhesion
    GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
    GO:42326; negative regulation of phosphorylation
    GO:45892; negative regulation of transcription, DNA-templated
    And 6 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5634; nucleus
    GO:35985; senescence-associated heterochromatin focus
    Function: GO:51059; NF-kappaB binding
    GO:3723; RNA binding
    GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
    GO:5515; protein binding
    GO:19901; protein kinase binding
    Show all GO terms

    Homologs of CDKN2A in Model Organisms

    No homologs found

    In other databases

    GenAge human genes
    • This gene is present as CDKN2A
    LongevityMap
    • This gene is present as CDKN2A

    External links

    OMIM
    600160
    Ensembl
    ENSG00000147889
    Entrez Gene
    1029
    UniGene
    512599
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN2A
    GeneCards
    CDKN2A