Cell Senescence Entries for CDKN1C

Cell Types
Liver cancer
Cell Lines
HepG2, SNU-398
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Upregulation of CDKN1C by cDNA transfection in liver cancer cells decreased tumor growth and resulted in a flat and lengthened cell morphology, increased SA-beta-galactosidase activity and increased p16 expression.
Primary Reference

    CDKN1C Gene Information

    HGNC symbol
    CDKN1C 
    Aliases
    BWS; WBS; p57; BWCR; KIP2; p57Kip2 
    Common name
    cyclin dependent kinase inhibitor 1C 
    Entrez Id
    1028
    Description
    This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

    CDKN1C Ontologies

    Gene Ontology
    Process: GO:30325; adrenal gland development
    GO:7568; aging
    GO:43010; camera-type eye development
    GO:7050; cell cycle arrest
    GO:55123; digestive system development
    GO:60669; embryonic placenta morphogenesis
    GO:71514; genetic imprinting
    GO:1822; kidney development
    GO:35264; multicellular organism growth
    GO:30099; myeloid cell differentiation
    GO:1904030; negative regulation of cyclin-dependent protein kinase activity
    And 14 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:4860; protein kinase inhibitor activity
    Show all GO terms

    Homologs of CDKN1C in Model Organisms

    Mus musculus
    Cdkn1c
    Rattus norvegicus
    Cdkn1c

    External links

    OMIM
    600856
    Ensembl
    ENSG00000129757
    Entrez Gene
    1028
    UniGene
    106070
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN1C
    GeneCards
    CDKN1C