Cell Senescence Entries for CDKN1B

Cell Types
Lung fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
p27 (CDKN1B) is a common marker of senescence. Ectopic expression of p27 in young human diploid fibroblasts (TIG-3) resulted in a significantly lower rate of division, induced features of replicative senescence in young cells and caused growth arrest.
Primary Reference

    CDKN1B Gene Information

    HGNC symbol
    CDKN1B 
    Aliases
    KIP1; MEN4; CDKN4; MEN1B; P27KIP1 
    Common name
    cyclin dependent kinase inhibitor 1B 
    Entrez Id
    1027
    Description
    This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

    CDKN1B Ontologies

    Gene Ontology
    Process: GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:82; G1/S transition of mitotic cell cycle
    GO:7219; Notch signaling pathway
    GO:48102; autophagic cell death
    GO:7050; cell cycle arrest
    GO:71236; cellular response to antibiotic
    GO:71285; cellular response to lithium ion
    GO:71407; cellular response to organic cyclic compound
    GO:48839; inner ear development
    GO:71850; mitotic cell cycle arrest
    GO:43066; negative regulation of apoptotic process
    And 31 more GO terms
    Cellular component: GO:31464; Cul4A-RING E3 ubiquitin ligase complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5768; endosome
    GO:43231; intracellular membrane-bounded organelle
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:30544; Hsp70 protein binding
    GO:51087; chaperone binding
    GO:30332; cyclin binding
    GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:19901; protein kinase binding
    GO:4860; protein kinase inhibitor activity
    GO:19903; protein phosphatase binding
    GO:5072; transforming growth factor beta receptor, cytoplasmic mediator activity
    Show all GO terms

    Homologs of CDKN1B in Model Organisms

    Caenorhabditis elegans
    cki-2
    Danio rerio
    cdkn1ba
    Mus musculus
    Cdkn1b
    Rattus norvegicus
    Cdkn1b

    In other databases

    LongevityMap
    • This gene is present as CDKN1B

    External links

    OMIM
    600778
    Ensembl
    ENSG00000111276
    Entrez Gene
    1027
    UniGene
    238990
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN1B
    GeneCards
    CDKN1B