Cell Senescence Entries for CDKN1A

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
p21 (CDKN1A) is a common marker of senescence. Inactivation of p21 in normal diploid human fibroblasts resulted in a bypass of replicative senescence. After an initial decline in proliferation, fibroblast cells resumed growth and cultures containing a high proportion of senescent cells spontaneously give rise to new, non-senescent colonies.
Primary Reference

    CDKN1A Gene Information

    HGNC symbol
    CDKN1A 
    Aliases
    P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 
    Common name
    cyclin dependent kinase inhibitor 1A 
    Entrez Id
    1026
    Description
    This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]

    CDKN1A Ontologies

    Gene Ontology
    Process: GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:82; G1/S transition of mitotic cell cycle
    GO:86; G2/M transition of mitotic cell cycle
    GO:7265; Ras protein signal transduction
    GO:31100; animal organ regeneration
    GO:7050; cell cycle arrest
    GO:6974; cellular response to DNA damage stimulus
    GO:71493; cellular response to UV-B
    GO:34198; cellular response to amino acid starvation
    GO:31668; cellular response to extracellular stimulus
    And 37 more GO terms
    Cellular component: GO:70557; PCNA-p21 complex
    GO:307; cyclin-dependent protein kinase holoenzyme complex
    GO:5829; cytosol
    GO:16604; nuclear body
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    GO:43234; protein complex
    Function: GO:30332; cyclin binding
    GO:19912; cyclin-dependent protein kinase activating kinase activity
    GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:19901; protein kinase binding
    GO:4860; protein kinase inhibitor activity
    GO:31625; ubiquitin protein ligase binding
    Show all GO terms

    Homologs of CDKN1A in Model Organisms

    Danio rerio
    cdkn1a
    Mus musculus
    Cdkn1a
    Rattus norvegicus
    Cdkn1a

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Cdkn1a
    GenAge human genes
    • This gene is present as CDKN1A
    LongevityMap
    • This gene is present as CDKN1A

    External links

    OMIM
    116899
    Ensembl
    ENSG00000124762
    Entrez Gene
    1026
    UniGene
    370771
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDKN1A
    GeneCards
    CDKN1A