Cell Senescence Entries for CDK6

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of CDK6 in near senescent foreskin fibroblasts resulted in an increase in their replicative capacity.
Primary Reference

    CDK6 Gene Information

    HGNC symbol
    CDK6 
    Aliases
    MCPH12; PLSTIRE 
    Common name
    cyclin dependent kinase 6 
    Entrez Id
    1021
    Description
    The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

    CDK6 Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:14002; astrocyte development
    GO:7050; cell cycle arrest
    GO:43697; cell dedifferentiation
    GO:51301; cell division
    GO:1904628; cellular response to phorbol 13-acetate 12-myristate
    GO:21542; dentate gyrus development
    GO:48699; generation of neurons
    GO:42063; gliogenesis
    GO:21670; lateral ventricle development
    GO:45786; negative regulation of cell cycle
    And 18 more GO terms
    Cellular component: GO:5813; centrosome
    GO:307; cyclin-dependent protein kinase holoenzyme complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:1726; ruffle
    Function: GO:5524; ATP binding
    GO:98770; FBXO family protein binding
    GO:30332; cyclin binding
    GO:4693; cyclin-dependent protein serine/threonine kinase activity
    GO:5515; protein binding
    Show all GO terms

    Homologs of CDK6 in Model Organisms

    Danio rerio
    cdk6
    Mus musculus
    Cdk6
    Rattus norvegicus
    Cdk6

    In other databases

    LongevityMap
    • This gene is present as CDK6

    External links

    OMIM
    603368
    Ensembl
    ENSG00000105810
    Entrez Gene
    1021
    UniGene
    119882
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDK6
    GeneCards
    CDK6