Cell Senescence Entries for CDK4
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Overexpression of CDK4 in near senescent foreskin fibroblasts resulted in an increase in their replicative capacity.
- Primary Reference
CDK4 Gene Information
- HGNC symbol
- CDK4
- Aliases
- CMM3; PSK-J3
- Common name
- cyclin dependent kinase 4
- Entrez Id
- 1019
- Description
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
CDK4 Ontologies
- Gene Ontology
-
Process: GO:82; G1/S transition of mitotic cell cycle
GO:60612; adipose tissue development
GO:31100; animal organ regeneration
GO:51301; cell division
GO:32869; cellular response to insulin stimulus
GO:71353; cellular response to interleukin-4
GO:1904637; cellular response to ionomycin
GO:71222; cellular response to lipopolysaccharide
GO:1904628; cellular response to phorbol 13-acetate 12-myristate
GO:7623; circadian rhythm
GO:2088; lens development in camera-type eye
And 24 more GO terms Cellular component: GO:5923; bicellular tight junction
GO:785; chromatin
GO:97129; cyclin D2-CDK4 complex
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:5829; cytosol
GO:31965; nuclear membrane
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5634; nucleus
GO:48471; perinuclear region of cytoplasm
GO:5667; transcription factor complex
And 1 more GO terms Function: GO:5524; ATP binding
GO:30332; cyclin binding
GO:4693; cyclin-dependent protein serine/threonine kinase activity
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
GO:5515; protein binding
GO:32403; protein complex binding
Homologs of CDK4 in Model Organisms
External links
- OMIM
- 123829
- Ensembl
- ENSG00000135446
- Entrez Gene
- 1019
- UniGene
- 95577
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDK4
- GeneCards
- CDK4