Cell Senescence Entries for CDK4

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of CDK4 in near senescent foreskin fibroblasts resulted in an increase in their replicative capacity.
Primary Reference

    CDK4 Gene Information

    HGNC symbol
    CDK4 
    Aliases
    CMM3; PSK-J3 
    Common name
    cyclin dependent kinase 4 
    Entrez Id
    1019
    Description
    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

    CDK4 Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:60612; adipose tissue development
    GO:31100; animal organ regeneration
    GO:51301; cell division
    GO:32869; cellular response to insulin stimulus
    GO:71353; cellular response to interleukin-4
    GO:1904637; cellular response to ionomycin
    GO:71222; cellular response to lipopolysaccharide
    GO:1904628; cellular response to phorbol 13-acetate 12-myristate
    GO:7623; circadian rhythm
    GO:2088; lens development in camera-type eye
    And 24 more GO terms
    Cellular component: GO:5923; bicellular tight junction
    GO:785; chromatin
    GO:97129; cyclin D2-CDK4 complex
    GO:307; cyclin-dependent protein kinase holoenzyme complex
    GO:5829; cytosol
    GO:31965; nuclear membrane
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    GO:5667; transcription factor complex
    And 1 more GO terms
    Function: GO:5524; ATP binding
    GO:30332; cyclin binding
    GO:4693; cyclin-dependent protein serine/threonine kinase activity
    GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
    GO:5515; protein binding
    GO:32403; protein complex binding
    Show all GO terms

    Homologs of CDK4 in Model Organisms

    Danio rerio
    cdk4
    Drosophila melanogaster
    Cdk4
    Mus musculus
    Cdk4
    Rattus norvegicus
    Cdk4

    External links

    OMIM
    123829
    Ensembl
    ENSG00000135446
    Entrez Gene
    1019
    UniGene
    95577
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDK4
    GeneCards
    CDK4