Cell Senescence Entries for CDK2AP1

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of CDK2AP1 (using short-hairpin RNA) in human dermal fibroblasts resulted in reduced proliferation and increased SA-beta-galactosidase activity.
Primary Reference

    CDK2AP1 Gene Information

    HGNC symbol
    CDK2AP1 
    Aliases
    DOC1; ST19; DORC1; doc-1; p12DOC-1 
    Common name
    cyclin dependent kinase 2 associated protein 1 
    Entrez Id
    8099
    Description
    The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

    CDK2AP1 Ontologies

    Gene Ontology
    Process: GO:6261; DNA-dependent DNA replication
    GO:7049; cell cycle
    GO:1934; positive regulation of protein phosphorylation
    Cellular component: GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    Function: GO:70182; DNA polymerase binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of CDK2AP1 in Model Organisms

    Mus musculus
    Cdk2ap1
    Rattus norvegicus
    Cdk2ap1

    External links

    OMIM
    602198
    Ensembl
    ENSG00000111328
    Entrez Gene
    8099
    UniGene
    433201
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDK2AP1
    GeneCards
    CDK2AP1