Cell Senescence Entries for CDK18

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    CDK18 Gene Information

    HGNC symbol
    CDK18 
    Aliases
    PCTK3; PCTAIRE; PCTAIRE3 
    Common name
    cyclin dependent kinase 18 
    Entrez Id
    5129
    Description

    CDK18 Ontologies

    Gene Ontology
    Process: GO:6468; protein phosphorylation
    Cellular component: GO:5575; cellular_component
    GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4693; cyclin-dependent protein serine/threonine kinase activity
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of CDK18 in Model Organisms

    Caenorhabditis elegans
    pct-1
    Danio rerio
    LOC100150007
    Mus musculus
    Cdk18
    Rattus norvegicus
    Cdk18

    External links

    OMIM
    169190
    Ensembl
    ENSG00000117266
    Entrez Gene
    5129
    UniGene
    445402
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CDK18
    GeneCards
    CDK18