Cell Senescence Entries for CCND1

Cell Types
Fibroblast
Cell Lines
WI-38, Hs68
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Endogenous or ectopical expression of cyclin D1 (CCND1) in normal human diploid fibroblasts resulted in replicative senescence, with cells being unable to enter the S phase. Moreover, senescent cells expressed significantly higher levels of cyclin D1 than control cells.
Primary Reference

    CCND1 Gene Information

    HGNC symbol
    CCND1 
    Aliases
    BCL1; PRAD1; U21B31; D11S287E 
    Common name
    cyclin D1 
    Entrez Id
    595
    Description
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

    CCND1 Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:33327; Leydig cell differentiation
    GO:60070; canonical Wnt signaling pathway
    GO:51301; cell division
    GO:6974; cellular response to DNA damage stimulus
    GO:30968; endoplasmic reticulum unfolded protein response
    GO:45444; fat cell differentiation
    GO:7595; lactation
    GO:97421; liver regeneration
    GO:60749; mammary gland alveolus development
    GO:33598; mammary gland epithelial cell proliferation
    And 27 more GO terms
    Cellular component: GO:5923; bicellular tight junction
    GO:307; cyclin-dependent protein kinase holoenzyme complex
    GO:5829; cytosol
    GO:5622; intracellular
    GO:16020; membrane
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:17053; transcriptional repressor complex
    Function: GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
    GO:19899; enzyme binding
    GO:42826; histone deacetylase binding
    GO:70064; proline-rich region binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:4672; protein kinase activity
    GO:19901; protein kinase binding
    GO:3714; transcription corepressor activity
    GO:8134; transcription factor binding
    Show all GO terms

    Homologs of CCND1 in Model Organisms

    Danio rerio
    ccnd1
    Mus musculus
    Ccnd1
    Rattus norvegicus
    Ccnd1

    In other databases

    LongevityMap
    • This gene is present as CCND1

    External links

    OMIM
    168461
    Ensembl
    ENSG00000110092
    Entrez Gene
    595
    UniGene
    523852
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CCND1
    GeneCards
    CCND1