Cell Senescence Entries for CBX8

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Inhibition of CBX8 expression lead to a complete growth arrest and increased levels of p16 in telomerase-immortalized TIG-3 human diploid fibroblasts. Moreover, overexpressing CBX8 bypassed oncogene- and stress-induced senescence in mouse embryonic fibroblasts.
Primary Reference

    CBX8 Gene Information

    HGNC symbol
    CBX8 
    Aliases
    PC3; RC1 
    Common name
    chromobox 8 
    Entrez Id
    57332
    Description

    CBX8 Ontologies

    Gene Ontology
    Process: GO:70301; cellular response to hydrogen peroxide
    GO:16574; histone ubiquitination
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45739; positive regulation of DNA repair
    GO:8284; positive regulation of cell proliferation
    GO:32967; positive regulation of collagen biosynthetic process
    GO:50790; regulation of catalytic activity
    GO:6351; transcription, DNA-templated
    Cellular component: GO:35102; PRC1 complex
    GO:31519; PcG protein complex
    GO:792; heterochromatin
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:35064; methylated histone binding
    GO:5515; protein binding
    GO:3727; single-stranded RNA binding
    GO:97027; ubiquitin-protein transferase activator activity
    Show all GO terms

    Homologs of CBX8 in Model Organisms

    Danio rerio
    cbx8b
    Mus musculus
    Cbx8
    Rattus norvegicus
    Cbx8

    External links

    OMIM
    617354
    Ensembl
    ENSG00000141570
    Entrez Gene
    57332
    UniGene
    387258
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CBX8
    GeneCards
    CBX8