Cell Senescence Entries for CAV1

Cell Types
Fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
CAV1 reduction through RNA interference reversed some of the morphological changes of senescent foreskin fibroblasts.
Primary Reference

    CAV1 Gene Information

    HGNC symbol
    CAV1 
    Aliases
    CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085 
    Common name
    caveolin 1 
    Entrez Id
    857
    Description
    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

    CAV1 Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:31295; T cell costimulation
    GO:1525; angiogenesis
    GO:86098; angiotensin-activated signaling pathway involved in heart process
    GO:97190; apoptotic signaling pathway
    GO:1904886; beta-catenin destruction complex disassembly
    GO:55074; calcium ion homeostasis
    GO:6816; calcium ion transport
    GO:70836; caveola assembly
    GO:72584; caveolin-mediated endocytosis
    GO:6874; cellular calcium ion homeostasis
    And 84 more GO terms
    Cellular component: GO:139; Golgi membrane
    GO:34098; VCP-NPL4-UFD1 AAA ATPase complex
    GO:2080; acrosomal membrane
    GO:5901; caveola
    GO:5938; cell cortex
    GO:5929; cilium
    GO:31410; cytoplasmic vesicle
    GO:31901; early endosome membrane
    GO:30666; endocytic vesicle membrane
    GO:5783; endoplasmic reticulum
    GO:5789; endoplasmic reticulum membrane
    And 11 more GO terms
    Function: GO:51117; ATPase binding
    GO:48365; Rac GTPase binding
    GO:15485; cholesterol binding
    GO:19899; enzyme binding
    GO:42802; identical protein binding
    GO:70320; inward rectifier potassium channel inhibitor activity
    GO:44325; ion channel binding
    GO:50998; nitric-oxide synthase binding
    GO:5113; patched binding
    GO:16504; peptidase activator activity
    GO:5515; protein binding
    And 7 more GO terms
    Show all GO terms

    Homologs of CAV1 in Model Organisms

    Danio rerio
    cav1
    Mus musculus
    Cav1
    Rattus norvegicus
    Cav1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Cav1

    External links

    OMIM
    601047
    Ensembl
    ENSG00000105974
    Entrez Gene
    857
    UniGene
    74034
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CAV1
    GeneCards
    CAV1