Cell Senescence Entries for C11orf31

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
SelH (C11orf31) was knocked down in lung fibroblasts (MCR-5). SelH shRNA MRC-5 cells under ambient O2 displayed a distinct profile of senescence including increased SA-beta-galactosidase expression, autofluorescence, growth inhibition, and ATM pathway activation. Such senescence phenotypes were alleviated in the presence of ATM kinase inhibitors, p53 shRNA knockdown or by maintaining the cells under 3% O2.
Primary Reference

    C11orf31 Gene Information

    HGNC symbol
    C11orf31 
    Aliases
    SELH; C11orf31; C17orf10 
    Common name
    selenoprotein H 
    Entrez Id
    280636
    Description
    This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]

    SELENOH Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function: GO:3723; RNA binding
    Show all GO terms

    Homologs of SELENOH in Model Organisms

    Danio rerio
    seph
    Mus musculus
    Selh

    External links

    OMIM
    607914
    Ensembl
    ENSG00000211450
    Entrez Gene
    280636
    UniGene
    655373
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    C11orf31
    GeneCards
    C11orf31