Cell Senescence Entries for BTG3

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Loss of BTG3 in normal lung fibroblasts induced cellular senescence, exhibiting enhanced ERK-AP1 signalling and elevated expression of the histone H3K27 demethylase JMJD3/KDM6B, leading to acute induction of p16, a senescence associated kinase inhibitor.
Primary Reference

    BTG3 Gene Information

    HGNC symbol
    BTG3 
    Aliases
    ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3 
    Common name
    BTG anti-proliferation factor 3 
    Entrez Id
    10950
    Description
    The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

    BTG3 Ontologies

    Gene Ontology
    Process: GO:8285; negative regulation of cell proliferation
    GO:45930; negative regulation of mitotic cell cycle
    Cellular component: GO:5737; cytoplasm
    Function: GO:5515; protein binding
    Show all GO terms

    Homologs of BTG3 in Model Organisms

    Danio rerio
    btg3
    Mus musculus
    Btg3
    Rattus norvegicus
    Btg3

    In other databases

    LongevityMap
    • This gene is present as BTG3

    External links

    OMIM
    605674
    Ensembl
    ENSG00000154640
    Entrez Gene
    10950
    UniGene
    473420
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BTG3
    GeneCards
    BTG3