Cell Senescence Entries for BRD7

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
BRD7 depletion significantly delayed replicative senescence and increased proliferation rate in both young and mid-passage foreskin fibroblasts. Contrastly, overexpression of BRD7 induced premature senescence.
Primary Reference

    BRD7 Gene Information

    HGNC symbol
    BRD7 
    Aliases
    BP75; NAG4; CELTIX1 
    Common name
    bromodomain containing 7 
    Entrez Id
    29117
    Description
    This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

    BRD7 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:7049; cell cycle
    GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
    GO:8285; negative regulation of cell proliferation
    GO:45892; negative regulation of transcription, DNA-templated
    GO:35066; positive regulation of histone acetylation
    GO:45893; positive regulation of transcription, DNA-templated
    GO:1901796; regulation of signal transduction by p53 class mediator
    GO:6357; regulation of transcription from RNA polymerase II promoter
    GO:6351; transcription, DNA-templated
    Cellular component: GO:90544; BAF-type complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:42393; histone binding
    GO:70577; lysine-acetylated histone binding
    GO:2039; p53 binding
    GO:5515; protein binding
    GO:3713; transcription coactivator activity
    GO:3714; transcription corepressor activity
    GO:8134; transcription factor binding
    GO:44212; transcription regulatory region DNA binding
    Show all GO terms

    Homologs of BRD7 in Model Organisms

    Danio rerio
    brd7
    Mus musculus
    Brd7
    Rattus norvegicus
    Brd7

    External links

    OMIM
    Ensembl
    ENSG00000166164
    Entrez Gene
    29117
    UniGene
    437894
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BRD7
    GeneCards
    BRD7