Cell Senescence Entries for BRCA1

Cell Types
Breast cancer
Cell Lines
HBL100, MCF-7, HCC1937
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
BRCA1 deficiency resulted in increased senescence after induced DNA damage through drugs that generate intra- and interstrand cross links.
Primary Reference

    BRCA1 Gene Information

    HGNC symbol
    BRCA1 
    Aliases
    IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53 
    Common name
    BRCA1, DNA repair associated 
    Entrez Id
    672
    Description
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]

    BRCA1 Ontologies

    Gene Ontology
    Process: GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:729; DNA double-strand break processing
    GO:6260; DNA replication
    GO:731; DNA synthesis involved in DNA repair
    GO:31572; G2 DNA damage checkpoint
    GO:30521; androgen receptor signaling pathway
    GO:6915; apoptotic process
    GO:6974; cellular response to DNA damage stimulus
    GO:71681; cellular response to indole-3-methanol
    GO:71356; cellular response to tumor necrosis factor
    GO:7098; centrosome cycle
    And 49 more GO terms
    Cellular component: GO:70531; BRCA1-A complex
    GO:31436; BRCA1-BARD1 complex
    GO:5694; chromosome
    GO:5737; cytoplasm
    GO:8274; gamma-tubulin ring complex
    GO:30529; intracellular ribonucleoprotein complex
    GO:800; lateral element
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:43234; protein complex
    And 2 more GO terms
    Function: GO:3677; DNA binding
    GO:3723; RNA binding
    GO:50681; androgen receptor binding
    GO:3684; damaged DNA binding
    GO:19899; enzyme binding
    GO:5515; protein binding
    GO:3713; transcription coactivator activity
    GO:44212; transcription regulatory region DNA binding
    GO:15631; tubulin binding
    GO:31625; ubiquitin protein ligase binding
    GO:4842; ubiquitin-protein transferase activity
    And 2 more GO terms
    Show all GO terms

    Homologs of BRCA1 in Model Organisms

    Mus musculus
    Brca1
    Rattus norvegicus
    Brca1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Brca1
    GenAge human genes
    • This gene is present as BRCA1
    LongevityMap
    • This gene is present as BRCA1

    External links

    OMIM
    113705
    Ensembl
    ENSG00000012048
    Entrez Gene
    672
    UniGene
    194143
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BRCA1
    GeneCards
    BRCA1