Cell Senescence Entries for BRAF

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
Primary cell, BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Retroviral delivery of BRAF into normal human fibroblasts resulted in a cessation of proliferation, along with induction of senescence associated p16.
Primary Reference

    BRAF Gene Information

    HGNC symbol
    BRAF 
    Aliases
    NS7; B-raf; BRAF1; RAFB1; B-RAF1 
    Common name
    B-Raf proto-oncogene, serine/threonine kinase 
    Entrez Id
    673
    Description
    This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]

    BRAF Ontologies

    Gene Ontology
    Process: GO:43369; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
    GO:43367; CD4-positive, alpha-beta T cell differentiation
    GO:165; MAPK cascade
    GO:50852; T cell receptor signaling pathway
    GO:186; activation of MAPKK activity
    GO:9887; animal organ morphogenesis
    GO:30154; cell differentiation
    GO:71277; cellular response to calcium ion
    GO:35690; cellular response to drug
    GO:1990090; cellular response to nerve growth factor stimulus
    GO:90150; establishment of protein localization to membrane
    And 29 more GO terms
    Cellular component: GO:44297; cell body
    GO:5829; cytosol
    GO:5622; intracellular
    GO:43231; intracellular membrane-bounded organelle
    GO:5739; mitochondrion
    GO:43005; neuron projection
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:4709; MAP kinase kinase kinase activity
    GO:5509; calcium ion binding
    GO:42802; identical protein binding
    GO:31434; mitogen-activated protein kinase kinase binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    GO:31267; small GTPase binding
    Show all GO terms

    Homologs of BRAF in Model Organisms

    Danio rerio
    braf
    Mus musculus
    Braf
    Rattus norvegicus
    Braf

    External links

    OMIM
    164757
    Ensembl
    ENSG00000157764
    Entrez Gene
    673
    UniGene
    550061
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BRAF
    GeneCards
    BRAF