Cell Senescence Entries for BMI1

Cell Types
Foreskin fibroblast, Lung fibroblast, Skin fibroblast
Cell Lines
WI-38, BJ, 82-6
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of BMI1 extended replicative life span in WI-38 human fibroblasts. BMI1 was also downregulated when fibroblasts underwent replicative senescence, but not quiescence.
Primary Reference

    BMI1 Gene Information

    HGNC symbol
    BMI1 
    Aliases
    PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1 
    Common name
    BMI1 proto-oncogene, polycomb ring finger 
    Entrez Id
    648
    Description
    This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

    BMI1 Ontologies

    Gene Ontology
    Process: GO:16569; covalent chromatin modification
    GO:30097; hemopoiesis
    GO:45814; negative regulation of gene expression, epigenetic
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:48146; positive regulation of fibroblast proliferation
    GO:51443; positive regulation of ubiquitin-protein transferase activity
    GO:10468; regulation of gene expression
    GO:7379; segment specification
    GO:6351; transcription, DNA-templated
    Cellular component: GO:35102; PRC1 complex
    GO:31519; PcG protein complex
    GO:5829; cytosol
    GO:16604; nuclear body
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:151; ubiquitin ligase complex
    Function: GO:71535; RING-like zinc finger domain binding
    GO:1990841; promoter-specific chromatin binding
    GO:5515; protein binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of BMI1 in Model Organisms

    Danio rerio
    bmi1a
    Mus musculus
    Bmi1
    Rattus norvegicus
    Bmi1

    In other databases

    GenAge human genes
    • This gene is present as BMI1

    External links

    OMIM
    164831
    Ensembl
    ENSG00000168283
    Entrez Gene
    648
    UniGene
    380403
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BMI1
    GeneCards
    BMI1