Cell Senescence Entries for BLK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    BLK Gene Information

    HGNC symbol
    BLK 
    Aliases
    MODY11 
    Common name
    BLK proto-oncogene, Src family tyrosine kinase 
    Entrez Id
    640
    Description
    This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

    BLK Ontologies

    Gene Ontology
    Process: GO:50853; B cell receptor signaling pathway
    GO:30154; cell differentiation
    GO:16477; cell migration
    GO:45087; innate immune response
    GO:35556; intracellular signal transduction
    GO:38083; peptidyl-tyrosine autophosphorylation
    GO:32024; positive regulation of insulin secretion
    GO:42127; regulation of cell proliferation
    GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
    Cellular component: GO:31234; extrinsic component of cytoplasmic side of plasma membrane
    Function: GO:5524; ATP binding
    GO:4715; non-membrane spanning protein tyrosine kinase activity
    GO:5515; protein binding
    GO:4713; protein tyrosine kinase activity
    GO:5102; receptor binding
    Show all GO terms

    Homologs of BLK in Model Organisms

    Caenorhabditis elegans
    src-1
    Danio rerio
    blk
    Mus musculus
    Blk
    Rattus norvegicus
    Blk

    External links

    OMIM
    191305
    Ensembl
    ENSG00000136573
    Entrez Gene
    640
    UniGene
    146591
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BLK
    GeneCards
    BLK