Cell Senescence Entries for BLK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

BLK Gene Information

HGNC symbol
BLK 
Aliases
MGC10442 
Common name
BLK proto-oncogene, Src family tyrosine kinase 
Entrez Id
640
Description
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010].

BLK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:45087; innate immune response
GO:30154; cell differentiation
GO:6974; cellular response to DNA damage stimulus
GO:31175; neuron projection development
GO:50853; B cell receptor signaling pathway
GO:32092; positive regulation of protein binding
GO:35556; intracellular signal transduction
GO:30889; negative regulation of B cell proliferation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
And 13 more GO terms
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:5737; cytoplasm
Function: GO:5524; ATP binding
GO:5515; protein binding
GO:4672; protein kinase activity
GO:4713; protein tyrosine kinase activity
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:5102; signaling receptor binding
Show all GO terms

Homologs of BLK in Model Organisms

Caenorhabditis elegans
src-1
Danio rerio
blk
Drosophila melanogaster
Src64B
Mus musculus
Blk
Rattus norvegicus
Blk

External links

OMIM
191305
Ensembl
ENSG00000136573
Entrez Gene
640
UniGene
146591
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BLK
GeneCards
BLK