Cell Senescence Entries for BHLHE40

Cell Types
Esophageal cancer, Breast cancer
Cell Lines
EC9706, MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced, Replicative
Senescence Effect
Promotes
Observations
BHLHE40 overexpression induced cellular senescence and inhibited cell growth and colony formation in esophageal cancer cells (EC9706).
Primary Reference
    Cell Types
    Esophageal cancer, Breast cancer
    Cell Lines
    EC9706, MCF-7
    Cancer Cell?
    Yes
    Method
    Overexpression
    Type of senescence
    Stress-induced, Replicative
    Senescence Effect
    Promotes
    Observations
    BHLHE40 overexpression induced cellular senescence and inhibited cell growth and colony formation in esophageal cancer cells (EC9706).
    Primary Reference

      BHLHE40 Gene Information

      HGNC symbol
      BHLHE40 
      Aliases
      DEC1; HLHB2; BHLHB2; Clast5; SHARP2; STRA13; Stra14; SHARP-2 
      Common name
      basic helix-loop-helix family member e40 
      Entrez Id
      8553
      Description
      This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

      BHLHE40 Ontologies

      Gene Ontology
      Process: GO:32922; circadian regulation of gene expression
      GO:43153; entrainment of circadian clock by photoperiod
      GO:43433; negative regulation of sequence-specific DNA binding transcription factor activity
      GO:122; negative regulation of transcription from RNA polymerase II promoter
      GO:45892; negative regulation of transcription, DNA-templated
      GO:6355; regulation of transcription, DNA-templated
      GO:6351; transcription, DNA-templated
      Cellular component: GO:5737; cytoplasm
      GO:16604; nuclear body
      GO:5634; nucleus
      Function: GO:70888; E-box binding
      GO:43426; MRF binding
      GO:1102; RNA polymerase II activating transcription factor binding
      GO:981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
      GO:43425; bHLH transcription factor binding
      GO:5515; protein binding
      GO:19904; protein domain specific binding
      GO:46982; protein heterodimerization activity
      GO:42803; protein homodimerization activity
      GO:3714; transcription corepressor activity
      GO:3705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
      And 4 more GO terms
      Show all GO terms

      Homologs of BHLHE40 in Model Organisms

      Danio rerio
      bhlhe40
      Mus musculus
      Bhlhe40
      Rattus norvegicus
      Bhlhe40

      External links

      OMIM
      604256
      Ensembl
      ENSG00000134107
      Entrez Gene
      8553
      UniGene
      744856
      1000 Genomes
      1000 Genomes
      HPRD
      GenAtlas
      BHLHE40
      GeneCards
      BHLHE40