Cell Senescence Entries for BCL6

Cell Types
B-cell
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
BCL6 expression extended the replicative lifespan of primary human B cells and induced cyclin D1 expression, allowing cells to overcome the senescence program induced by the p19ARF-p53 pathway.
Primary Reference

    BCL6 Gene Information

    HGNC symbol
    BCL6 
    Aliases
    BCL5; LAZ3; BCL6A; ZNF51; ZBTB27 
    Common name
    B-cell CLL/lymphoma 6 
    Entrez Id
    604
    Description
    The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

    BCL6 Ontologies

    Gene Ontology
    Process: GO:30183; B cell differentiation
    GO:7266; Rho protein signal transduction
    GO:30036; actin cytoskeleton organization
    GO:902; cell morphogenesis
    GO:6974; cellular response to DNA damage stimulus
    GO:48821; erythrocyte development
    GO:2467; germinal center formation
    GO:6954; inflammatory response
    GO:2903; negative regulation of B cell apoptotic process
    GO:45746; negative regulation of Notch signaling pathway
    GO:35024; negative regulation of Rho protein signal transduction
    And 28 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5657; replication fork
    Function: GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:31490; chromatin DNA binding
    GO:3682; chromatin binding
    GO:42802; identical protein binding
    GO:1161; intronic transcription regulatory region sequence-specific DNA binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:1227; transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
    Show all GO terms

    Homologs of BCL6 in Model Organisms

    Danio rerio
    bcl6a
    Mus musculus
    Bcl6
    Rattus norvegicus
    Bcl6

    External links

    OMIM
    109565
    Ensembl
    ENSG00000113916
    Entrez Gene
    604
    UniGene
    478588
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BCL6
    GeneCards
    BCL6