Cell Senescence Entries for BAG3

Cell Types
Laryngeal cancer, Glioma
Cell Lines
A172, HEp2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Depletion of BIS (BAG3) induced G1 arrest and cellular senescence through the accumulation of p27, independent of p53, p21 or p16. The increased p27 expression in BIS-depleted cells was attributable to an impairment of the ubiquitin-mediated degradation of p27, which was caused by a decrease in S-phase kinase-associated protein 2 (SKP2) at the transcriptional level. As an underlying molecular mechanism, the loss of activity of signal transducer and activator of transcription 3 (STAT3) was specifically linked to the suppression of SKP2 expression.
Primary Reference

    BAG3 Gene Information

    HGNC symbol
    BAG3 
    Aliases
    BIS; MFM6; BAG-3; CAIR-1 
    Common name
    BCL2 associated athanogene 3 
    Entrez Id
    9531
    Description
    BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

    BAG3 Ontologies

    Gene Ontology
    Process: GO:7420; brain development
    GO:34605; cellular response to heat
    GO:71260; cellular response to mechanical stimulus
    GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
    GO:8625; extrinsic apoptotic signaling pathway via death domain receptors
    GO:43066; negative regulation of apoptotic process
    GO:10664; negative regulation of striated muscle cell apoptotic process
    GO:97201; negative regulation of transcription from RNA polymerase II promoter in response to stress
    GO:46827; positive regulation of protein export from nucleus
    GO:42993; positive regulation of transcription factor import into nucleus
    GO:6457; protein folding
    And 5 more GO terms
    Cellular component: GO:30018; Z disc
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:43005; neuron projection
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:774; adenyl-nucleotide exchange factor activity
    GO:45296; cadherin binding
    GO:51087; chaperone binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    Show all GO terms

    Homologs of BAG3 in Model Organisms

    Danio rerio
    bag3
    Drosophila melanogaster
    stv
    Mus musculus
    Bag3
    Rattus norvegicus
    Bag3

    External links

    OMIM
    603883
    Ensembl
    ENSG00000151929
    Entrez Gene
    9531
    UniGene
    523309
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BAG3
    GeneCards
    BAG3