Cell Senescence Entries for AXL

Cell Types
Lung fibroblast, Embryonic kidney
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    AXL Gene Information

    HGNC symbol
    AXL 
    Aliases
    ARK; UFO; JTK11; Tyro7 
    Common name
    AXL receptor tyrosine kinase 
    Entrez Id
    558
    Description
    The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

    AXL Ontologies

    Gene Ontology
    Process: GO:31100; animal organ regeneration
    GO:43277; apoptotic cell clearance
    GO:1974; blood vessel remodeling
    GO:48469; cell maturation
    GO:31668; cellular response to extracellular stimulus
    GO:70301; cellular response to hydrogen peroxide
    GO:35457; cellular response to interferon-alpha
    GO:71222; cellular response to lipopolysaccharide
    GO:97028; dendritic cell differentiation
    GO:34101; erythrocyte homeostasis
    GO:21885; forebrain cell migration
    And 27 more GO terms
    Cellular component: GO:9986; cell surface
    GO:70062; extracellular exosome
    GO:5615; extracellular space
    GO:44228; host cell surface
    GO:5887; integral component of plasma membrane
    GO:5622; intracellular
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:32036; myosin heavy chain binding
    GO:43548; phosphatidylinositol 3-kinase binding
    GO:1786; phosphatidylserine binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:4713; protein tyrosine kinase activity
    GO:4714; transmembrane receptor protein tyrosine kinase activity
    GO:1618; virus receptor activity
    Show all GO terms

    Homologs of AXL in Model Organisms

    Mus musculus
    Axl
    Rattus norvegicus
    Axl

    External links

    OMIM
    109135
    Ensembl
    ENSG00000167601
    Entrez Gene
    558
    UniGene
    590970
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    AXL
    GeneCards
    AXL