Cell Senescence Entries for ATM

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
MRC-5, WI-38, BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Human diploid fibroblasts from ataxia telangiectasia (an autosomal recessive disease caused by defects in the ATM gene) patients had an accelerated rate of telomere shortening and underwent premature cellular senescence compared to control cultures.
Primary Reference

    ATM Gene Information

    HGNC symbol
    ATM 
    Aliases
    AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1 
    Common name
    ATM serine/threonine kinase 
    Entrez Id
    472
    Description
    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

    ATM Ontologies

    Gene Ontology
    Process: GO:6975; DNA damage induced protein phosphorylation
    GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:729; DNA double-strand break processing
    GO:6260; DNA replication
    GO:731; DNA synthesis involved in DNA repair
    GO:33151; V(D)J recombination
    GO:7420; brain development
    GO:7050; cell cycle arrest
    GO:6974; cellular response to DNA damage stimulus
    GO:71481; cellular response to X-ray
    GO:71480; cellular response to gamma radiation
    And 52 more GO terms
    Cellular component: GO:1990391; DNA repair complex
    GO:781; chromosome, telomeric region
    GO:31410; cytoplasmic vesicle
    GO:784; nuclear chromosome, telomeric region
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5819; spindle
    Function: GO:16303; 1-phosphatidylinositol-3-kinase activity
    GO:5524; ATP binding
    GO:3677; DNA binding
    GO:4677; DNA-dependent protein kinase activity
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:46983; protein dimerization activity
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of ATM in Model Organisms

    Danio rerio
    atm
    Drosophila melanogaster
    tefu
    Mus musculus
    Atm
    Rattus norvegicus
    Atm

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Atm
    GenAge human genes
    • This gene is present as ATM
    LongevityMap
    • This gene is present as ATM

    External links

    OMIM
    607585
    Ensembl
    ENSG00000149311
    Entrez Gene
    472
    UniGene
    367437
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ATM
    GeneCards
    ATM