Cell Senescence Entries for ATF7IP

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Depletion of MCAF1 (ATF7IP) in fibroblasts induced premature senescence that was characterized by cell cycle arrest, increased SA-beta-galactosidase activity and SA-heterochromatin foci formation.
Primary Reference

    ATF7IP Gene Information

    HGNC symbol
    ATF7IP 
    Aliases
    AM; MCAF; p621; MCAF1; ATF-IP 
    Common name
    activating transcription factor 7 interacting protein 
    Entrez Id
    55729
    Description
    ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

    ATF7IP Ontologies

    Gene Ontology
    Process: GO:6306; DNA methylation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45892; negative regulation of transcription, DNA-templated
    GO:45893; positive regulation of transcription, DNA-templated
    GO:45898; regulation of RNA polymerase II transcriptional preinitiation complex assembly
    GO:6351; transcription, DNA-templated
    GO:16032; viral process
    Cellular component: GO:5829; cytosol
    GO:16604; nuclear body
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5667; transcription factor complex
    Function: GO:16887; ATPase activity
    GO:5515; protein binding
    GO:3714; transcription corepressor activity
    Show all GO terms

    Homologs of ATF7IP in Model Organisms

    Danio rerio
    atf7ip
    Drosophila melanogaster
    wde
    Mus musculus
    Atf7ip
    Rattus norvegicus
    Atf7ip

    External links

    OMIM
    613644
    Ensembl
    ENSG00000171681
    Entrez Gene
    55729
    UniGene
    504856
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ATF7IP
    GeneCards
    ATF7IP