Cell Senescence Entries for ASPH

Cell Types
Liver cancer
Cell Lines
FOCUS, Huh7, HepG2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Inhibition of ASPH expression and enzymatic activity significantly reduced cell proliferation and colony formation but induced tumor cell senescence.
Primary Reference

    ASPH Gene Information

    HGNC symbol
    ASPH 
    Aliases
    AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1 
    Common name
    aspartate beta-hydroxylase 
    Entrez Id
    444
    Description
    This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]

    ASPH Ontologies

    Gene Ontology
    Process: GO:97202; activation of cysteine-type endopeptidase activity
    GO:60325; face morphogenesis
    GO:34220; ion transmembrane transport
    GO:35108; limb morphogenesis
    GO:6936; muscle contraction
    GO:8285; negative regulation of cell proliferation
    GO:55114; oxidation-reduction process
    GO:60021; palate development
    GO:7389; pattern specification process
    GO:42264; peptidyl-aspartic acid hydroxylation
    GO:45862; positive regulation of proteolysis
    And 4 more GO terms
    Cellular component: GO:32541; cortical endoplasmic reticulum
    GO:5783; endoplasmic reticulum
    GO:5789; endoplasmic reticulum membrane
    GO:16021; integral component of membrane
    GO:5886; plasma membrane
    GO:16529; sarcoplasmic reticulum
    GO:33017; sarcoplasmic reticulum membrane
    Function: GO:5509; calcium ion binding
    GO:9055; electron carrier activity
    GO:4597; peptide-aspartate beta-dioxygenase activity
    GO:5515; protein binding
    GO:8307; structural constituent of muscle
    GO:5198; structural molecule activity
    Show all GO terms

    Homologs of ASPH in Model Organisms

    Caenorhabditis elegans
    CELE_K09A9.6
    Danio rerio
    LOC559236
    Drosophila melanogaster
    Asph
    Mus musculus
    Asph

    External links

    OMIM
    600582
    Ensembl
    ENSG00000198363
    Entrez Gene
    444
    UniGene
    332422
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ASPH
    GeneCards
    ASPH