Cell Senescence Entries for ARPC1B

Cell Types
Osteosarcoma
Cell Lines
SaOs-2
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of p41-Arc (ARPC1B) induced a senescent phenotype in SaOs-2 osteosarcoma cells, which are deficient in p53 and Rb tumor suppressor genes, implying that p41 can induce senescence in a p53-independent manner.
Primary Reference

    ARPC1B Gene Information

    HGNC symbol
    ARPC1B 
    Aliases
    ARC41; p40-ARC; p41-ARC 
    Common name
    actin related protein 2/3 complex subunit 1B 
    Entrez Id
    10095
    Description
    This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

    ARPC1B Ontologies

    Gene Ontology
    Process: GO:34314; Arp2/3 complex-mediated actin nucleation
    GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
    GO:48013; ephrin receptor signaling pathway
    GO:6928; movement of cell or subcellular component
    GO:32355; response to estradiol
    GO:43627; response to estrogen
    Cellular component: GO:5885; Arp2/3 protein complex
    GO:15629; actin cytoskeleton
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5925; focal adhesion
    GO:36284; tubulobulbar complex
    Function: GO:51015; actin filament binding
    GO:5200; structural constituent of cytoskeleton
    Show all GO terms

    Homologs of ARPC1B in Model Organisms

    Caenorhabditis elegans
    arx-3
    Danio rerio
    arpc1b
    Drosophila melanogaster
    Arpc1
    Mus musculus
    Arpc1b
    Rattus norvegicus
    Arpc1b
    Saccharomyces cerevisiae
    ARC40
    Schizosaccharomyces pombe
    arc1

    External links

    OMIM
    604223
    Ensembl
    ENSG00000130429
    Entrez Gene
    10095
    UniGene
    489284
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ARPC1B
    GeneCards
    ARPC1B