Cell Senescence Entries for AR

Cell Types
Hair follicular keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of the androgen receptor (AR) promoted androgen-induced premature senescence in association with p16 upregulation, whereas AR knockdown diminished the effects of androgen.
Primary Reference

    AR Gene Information

    HGNC symbol
    AR 
    Aliases
    KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA 
    Common name
    androgen receptor 
    Entrez Id
    367
    Description
    The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

    AR Ontologies

    Gene Ontology
    Process: GO:33327; Leydig cell differentiation
    GO:60520; activation of prostate induction by androgen receptor signaling pathway
    GO:30521; androgen receptor signaling pathway
    GO:48645; animal organ formation
    GO:16049; cell growth
    GO:8283; cell proliferation
    GO:7267; cell-cell signaling
    GO:71383; cellular response to steroid hormone stimulus
    GO:71394; cellular response to testosterone stimulus
    GO:60742; epithelial cell differentiation involved in prostate gland development
    GO:3382; epithelial cell morphogenesis
    And 45 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:790; nuclear chromatin
    GO:16607; nuclear speck
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:43234; protein complex
    Function: GO:51117; ATPase binding
    GO:3677; DNA binding
    GO:70974; POU domain binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:4879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
    GO:1085; RNA polymerase II transcription factor binding
    GO:5497; androgen binding
    GO:4882; androgen receptor activity
    GO:8013; beta-catenin binding
    GO:3682; chromatin binding
    GO:19899; enzyme binding
    And 10 more GO terms
    Show all GO terms

    Homologs of AR in Model Organisms

    Danio rerio
    ar
    Mus musculus
    Ar
    Rattus norvegicus
    Ar

    In other databases

    GenAge human genes
    • This gene is present as AR

    External links

    OMIM
    313700
    Ensembl
    ENSG00000169083
    Entrez Gene
    367
    UniGene
    76704
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    AR
    GeneCards
    AR