Cell Senescence Entries for ALOX15B

Cell Types
Prostate epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of 15-LOX2 (ALOX15B) or its splice variants drove a fraction of young normal human prostate cells to cell-cycle arrest and cell senescence.
Primary Reference

    ALOX15B Gene Information

    HGNC symbol
    ALOX15B 
    Aliases
    15-LOX-2 
    Common name
    arachidonate 15-lipoxygenase, type B 
    Entrez Id
    247
    Description
    This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

    ALOX15B Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:19369; arachidonic acid metabolic process
    GO:51122; hepoxilin biosynthetic process
    GO:43651; linoleic acid metabolic process
    GO:6629; lipid metabolic process
    GO:19372; lipoxygenase pathway
    GO:45786; negative regulation of cell cycle
    GO:30336; negative regulation of cell migration
    GO:8285; negative regulation of cell proliferation
    GO:45926; negative regulation of growth
    GO:55114; oxidation-reduction process
    And 7 more GO terms
    Cellular component: GO:5856; cytoskeleton
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:19898; extrinsic component of membrane
    GO:5622; intracellular
    GO:16020; membrane
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:50473; arachidonate 15-lipoxygenase activity
    GO:36403; arachidonate 8(S)-lipoxygenase activity
    GO:5509; calcium ion binding
    GO:5506; iron ion binding
    GO:16165; linoleate 13S-lipoxygenase activity
    GO:8289; lipid binding
    Show all GO terms

    Homologs of ALOX15B in Model Organisms

    Danio rerio
    si:dkey-17e16.9
    Mus musculus
    Alox15b
    Rattus norvegicus
    Alox15b

    External links

    OMIM
    603697
    Ensembl
    ENSG00000179593
    Entrez Gene
    247
    UniGene
    111256
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ALOX15B
    GeneCards
    ALOX15B