Cell Senescence Entries for AKR1B1

Cell Types
Keratinocyte
Cell Lines
HaCat
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Overexpression of aldose reductase (AKR1B1) in HaCaT cells attenuated UVB-induced cellular damage and apoptosis, with a decreased generation of reactive oxygen species (ROS) and aldehydes - RNA interference or inhibition of aldose reductase abolished these effects.
Primary Reference

    AKR1B1 Gene Information

    HGNC symbol
    AKR1B1 
    Aliases
    AR; ADR; ALR2; ALDR1 
    Common name
    aldo-keto reductase family 1 member B 
    Entrez Id
    231
    Description
    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

    AKR1B1 Ontologies

    Gene Ontology
    Process: GO:6700; C21-steroid hormone biosynthetic process
    GO:5975; carbohydrate metabolic process
    GO:70301; cellular response to hydrogen peroxide
    GO:97238; cellular response to methylglyoxal
    GO:1901653; cellular response to peptide
    GO:44597; daunorubicin metabolic process
    GO:44598; doxorubicin metabolic process
    GO:46370; fructose biosynthetic process
    GO:72061; inner medullary collecting duct development
    GO:60135; maternal process involved in female pregnancy
    GO:18931; naphthalene metabolic process
    And 14 more GO terms
    Cellular component: GO:43220; Schmidt-Lanterman incisure
    GO:97454; Schwann cell microvillus
    GO:32838; cell projection cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5615; extracellular space
    GO:42629; mast cell granule
    GO:5654; nucleoplasm
    GO:33010; paranodal junction
    GO:48471; perinuclear region of cytoplasm
    Function: GO:4032; alditol:NADP+ 1-oxidoreductase activity
    GO:4033; aldo-keto reductase (NADP) activity
    GO:9055; electron carrier activity
    GO:43795; glyceraldehyde oxidoreductase activity
    Show all GO terms

    Homologs of AKR1B1 in Model Organisms

    Danio rerio
    akr1b1
    Mus musculus
    Akr1b1
    Rattus norvegicus
    Akr1b1

    External links

    OMIM
    103880
    Ensembl
    ENSG00000085662
    Entrez Gene
    231
    UniGene
    521212
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    AKR1B1
    GeneCards
    AKR1B1