Cell Senescence Entries for ADCK5

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    ADCK5 Gene Information

    HGNC symbol
    ADCK5 
    Aliases
     
    Common name
    aarF domain containing kinase 5 
    Entrez Id
    203054
    Description

    ADCK5 Ontologies

    Gene Ontology
    Process: GO:6468; protein phosphorylation
    Cellular component: GO:16021; integral component of membrane
    Function: GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of ADCK5 in Model Organisms

    Danio rerio
    adck5
    Drosophila melanogaster
    CG7616
    Mus musculus
    Adck5
    Rattus norvegicus
    Adck5
    Saccharomyces cerevisiae
    YLR253W
    Schizosaccharomyces pombe
    SPAC10F6.14c

    External links

    OMIM
    Ensembl
    ENSG00000173137
    Entrez Gene
    203054
    UniGene
    283374
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ADCK5
    GeneCards
    ADCK5